2023年10月12日,南華大學王丹玲教授和萬正卿為共同通訊作者在《Front Genet》雜志發(fā)表題為“Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma”的研究論文,該研究利用平行全基因組亞硫酸鹽測序(WGBS)和全基因組氧化亞硫酸氫測序(oxWGBS),在成對原發(fā)口腔鱗狀細胞癌樣本及其正常癌旁組織(NATs)中以單核苷酸分辨率表征5mC和5hmC圖譜,并采用多組學方法分析5mC和5hmc修飾對OSCC差異基因表達的影響。易基因科技為本研究提供oxWGBS+WGBS測序分析服務。
參考文獻:
Zhao W, Zhu L, Gong Q, Ma S, Xiong H, Su T, Wan Z, Wang D. Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma. Front Genet. 2023;14:1269084. pii: 1269084. doi: 10.3389/fgene.2023.1269084. PubMed PMID: 37900177.